--- product_id: 255644787 title: "Doctor's Best, SAM-e, 400 mg, 60 Enteric Coated Tablets" brand: "doctor's best" price: "€ 146.56" currency: EUR in_stock: true reviews_count: 6 url: https://www.desertcart.es/products/255644787-doctors-best-sam-e-400-mg-60-enteric-coated-tablets store_origin: ES region: Spain --- # 100% vegan & allergen-free 400 mg potent dose 18 clinical trials proven Doctor's Best, SAM-e, 400 mg, 60 Enteric Coated Tablets **Brand:** doctor's best **Price:** € 146.56 **Availability:** ✅ In Stock ## Summary > 💼 Elevate your mood and mobility with science-backed SAMe power! ## Quick Answers - **What is this?** Doctor's Best, SAM-e, 400 mg, 60 Enteric Coated Tablets by doctor's best - **How much does it cost?** € 146.56 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.es](https://www.desertcart.es/products/255644787-doctors-best-sam-e-400-mg-60-enteric-coated-tablets) ## Best For - doctor's best enthusiasts ## Why This Product - Trusted doctor's best brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Double Strength Dose:** 400 mg of pure, active S,S-SAMe per tablet for maximum efficacy. - • **Premium Italian Quality:** Pharmaceutical-grade SAMe with highest active isomer concentration on the market. - • **Clean & Conscious Formula:** Vegan, gluten-free, soy-free—crafted for the mindful professional. - • **Clinically Proven Support:** Backed by 18 controlled human trials over 40 years for mood, joint, and liver health. - • **Advanced Joint & Mood Boost:** Promotes joint comfort, mobility, and neurotransmitter synthesis for balanced wellbeing. ## Overview Doctor's Best SAM-e 400 mg delivers a potent, pharmaceutical-grade dose of the active S,S isomer of SAMe, clinically proven to support mood enhancement, joint comfort, and liver detoxification. This vegan, gluten-free, and soy-free formula is crafted with premium Italian SAMe, ensuring maximum bioavailability and efficacy for professionals seeking holistic cognitive and physical wellness. ## Description SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none. S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones. The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market. SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.* SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.* SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.* ## Features - Doctor's Best SAMe Double Strength is proven to enhance mood and promote cognitive health - SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine - SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification - SAMe's effectiveness has been proven with 18 controlled human trials published over 40 years - Pharmaceutical grade, Non-GMO, Gluten Free, Vegan ## Technical Specifications | Specification | Value | |---------------|-------| | Asin | B004YLAXOE | | Is Discontinued By Manufacturer | No | | Item Model Number | DRB-00252 | | Manufacturer | Doctor's Best | | Product Dimensions | 8.26 x 5.08 x 15.57 cm; 90.72 g | ## Product Details - **Brand:** Doctor's Best - **Diet type:** Vegan - **Flavour:** Unflavored - **Item dimensions L x W x H:** 8.3 x 5.1 x 15.6 centimeters - **Item form:** Tablet - **Item weight:** 91 g - **Primary supplement type:** Amino Acids - **Product benefits:** Detoxing - **Special ingredients:** Amino Acid - **Unit count:** 60 Count ## Images ![Doctor's Best, SAM-e, 400 mg, 60 Enteric Coated Tablets - Image 1](https://m.media-amazon.com/images/I/61qTxsnqhPL.jpg) ## Available Options This product comes in different **Size** options. ## Questions & Answers **Q: What are the benefits of Doctor’s Best SAM-e Double Strength?** A: This formula helps support emotional well-being, cognitive function, joint comfort, mobility, and liver health as part of overall wellness support.* **Q: Why are the tablets enteric coated?** A: The enteric coating is designed to help protect SAM-e through the stomach and support targeted release for improved absorption and gastrointestinal tolerance.* **Q: Should I take with food or on an empty stomach?** A: Doctor’s Best recommends taking ONE enteric coated tablet daily between meals on an empty stomach for optimal absorption. Do not chew or crush the tablet. **Q: What's the daily dosage?** A: Adults should take ONE 400 mg enteric coated tablet daily, or as recommended by a nutritionally informed physician. **Q: Is Doctor’s Best SAM-e Double Strength vegetarian?** A: Yes. Doctor’s Best SAM-e Double Strength is Non-GMO, Gluten Free, Soy Free, and Vegetarian. ## Customer Reviews ### ⭐ لم يعجبني *by on Reviewed in the United Arab Emirates 16 December 2023* لم يعجبني ### ⭐⭐⭐⭐⭐ Worked for me! *by on Reviewed in the United States 13 November 2013* Well it worked for me! I discovered Sam-e while doing some research on my own and decided to give it a try for my mild to moderate depression problems. It worked for me after about a week I started to notice a difference in my mood, I had more energy, and I was able to concentrate again. A few weeks after that i decided i didn't need it anymore and went off of it and a few days later I woke up feeling terrible with the same unpleasant feelings I had before I started taking it. Needless to say that night I went to the supermarket and bought some more. Now I just buy it from amazon because I know I need it and it offers the best value. I'll happily dish out forty bucks every two months if it helps me feel like this. I will note though that at first when I was switching brands I did have some gastrointestinal discomfort that was really unpleasant at first. It lasted off and on about three weeks, but then it stopped and I haven't had it since. I changed my diet to make sure I got about the same amount of fiber everyday to try and combat those problems and for me that seemed to work. I take one 400mg tablet every morning on an empty stomach and wait thirty minutes to an hour before eating anything. One time I ate something a few minutes after taking it and I did vomit so there's your warning, they actually do mean it when they say to wait to eat. Overall, I'm extremely happy with this product and if you don't believe these reviews look up some scholarly articles on it and the research speaks for itself, I believe they actually prescribe it for mild to moderate depression in countries like Germany. I've also read that st. john's wort works too for depression problems, but I've never tried it. A warning about st. john's though it can mess with the efficacy of birth control pills so I would be cautious about st. john's wort if you're taking birth control. ### ⭐⭐⭐⭐⭐ Realy helped my joint pain *by on Reviewed in Australia 28 January 2021* this product is worth buying it helped my joint pain and added calmness as well ## Frequently Bought Together - Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets - Doctor's Best SAM-e Mood & Joint Support & Liver Health (Pharmaceutical Grade/Non-GMO/Gluten Free/Vegetarian), Tablet, 60 Count (Pack of 1) - Doctors BEST High Absorption Magnesium Lysinate Glycinate 100% Chelated, Muscle Relaxation & Sleep Support, Non-GMO, Gluten Free, Soy Free, Vegan, 100% Chelated 240 Tablets --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.es/products/255644787-doctors-best-sam-e-400-mg-60-enteric-coated-tablets](https://www.desertcart.es/products/255644787-doctors-best-sam-e-400-mg-60-enteric-coated-tablets) --- *Product available on Desertcart Spain* *Store origin: ES* *Last updated: 2026-10-07*